I have strong world-builder tendencies, so I usually prefer to create my own homebrew settings rather than use published settings. The one significant exception is Freeport, for which I'm a crazed fanboy who's been lucky enough to contribute to the line.
I would love the opportunity to get more familiar with True20, but I was never able to put together a group for anything beyond a few one-shots. A new, really grabbing, setting might help with that, but it's far from a sure thing. Several of my friends who are fans of Tamora Pierce and Mercedes Lackey, and of Stephanie Pui-Min Law's artwork, bought Blue Rose
but nobody ever got a campaign going. And while I own both True20 Freeport books, I've only ever used v.3.0 and v.3.5 for that setting and have no plans to switch.
YMMV. I'm assuming a lot of the old-timers here have had an easier time recruiting players for True20 than I have!